Zoe Miltsakaki has worked as a contract archaeologist at the former 19th Ephorate of Prehistoric and Classical Antiquities. Between 1997-2007, she participated in many excavations of various sites and assisted with the cataloging of artifacts from the archaeological site of Zone. In 2011, she was appointed regular archaeologist at the former 15th Ephorate of Byzantine Antiquities. Her research interests focus mainly on the study of Roman and Byzantine material culture. Since 2018-2019, she has been involved in the systematic research and publication of important archeological sites that were discovered in the area of Evros during the construction of the Trans-Adriatic Gas Pipeline (TAP).